|Real name||Otto Octavius|
|First appearance||"The Amazing Spider-Man #16"|
When Otto was a child, his father altered his DNA so that he could control technology with his mind. It drove him to insanity, but he still became a respected scientist.
Mentor to Peter Parker
Otto became a teacher at Midtown High, where he mentored his two top students, Peter Parker and Gwen Stacy. He also developed a crush on fellow teacher Betty Ross. But he found out she was having an affair with Peter, so he quit his job and developed his tentacles.
Otto decided that he deserved a reward, so he created the dual identity of Doctor Octopus. He attacked the national bank of New York City, stealing thousands of dollars. He was confronted by Spider-Man, who easily defeated him, but Otto kept some of the money and escaped.
In their next battle, Otto was remarkably better at fighting. Spider-Man still evaded his tentacles, accidentally making Otto impale himself, which led to him bleeding to death. His last words to Peter were "This is all your fault".